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[1] In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. Step 1: Ethanol is oxidized (hydrogen atoms removed) in the liver by an enzyme called alcohol dehydrogenase, which converts the alcohol into acetaldehyde, a toxic metabolite. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage Antabuse is only available with a prescription from a physician. It is also being evaluated for its effectiveness in the treatment of cocaine use disorder, as well as in the treatment of HIV and certain types of cancer. The medication causes individuals to suffer from very unpleasant side effects ranging from headaches, nausea, and vomiting to weakness, mental confusion, and anxiety, when even trace amounts of alcohol have been ingested. Measurements of liver enzymes are useful for monitoring the treatment outcome as well as for detecting toxic effects on the liver. 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Withdrawal in the remaining patients was in no case related to adverse effects of disulfiram. This is then broken down further so that it can be removed from your body. Follow all directions on your prescription label. Take Antabuse exactly as directed by your doctor. Disulfiram should be used in conjunction with counseling and support. When the dehydrogenase enzyme is inhibited, acetaldehyde builds up, causing unpleasant side effects. You will need frequent blood tests to check your liver function Antabuse - Clinical Pharmacology Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Antabuse inhibits an enzyme, which assists in the breakdown of alcohol in the body. Contents 1 Medical uses 2 Side effects. 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A high degree of motivation to stop drinking leads to long-term use of Antabuse, a stronger internal locus of control and a favourable outcome. Relapses during treatment are the rule rather than the exception as is also illustrated in five case reports, but Antabuse treatment contributes to longer periods of sobriety. Within minutes after alcohol is consumed, a combination of the following symptoms can occur: Headache About 70% of the patients gave either "a wish to drink again" or "no need for further treatment" as the reason. Continued support by nurses is necessary. It comes in pill form and is taken with liquid How Antabuse Works When you consume alcohol, your body metabolizes it into acetaldehyde—a toxic substance that causes many of the hangover symptoms that occur after heavy drinking.